Epiregulation of the SASP makes good neighbors

Development of the renal glomerulus: good neighbors and good fences.

The glomerulus of the mammalian kidney is an intricate structure that contains an unusual filtration barrier that retains higher molecular weight proteins and blood cells in the circulation. Recent studies have changed our conception of the glomerulus from a relatively static structure to a dynamic one, whose integrity depends on signaling between the three major cell lineages: podocytes, endot...

Good Markets Make Bad Neighbors

In their manuscript, Corsaro, Hunt, Kroovand Hipple, and McGarrell (2012, this issue) provide a valuable contribution to the literature regarding focused deterrence with an econometric evaluation of the High Point Drug Market Intervention (DMI). By employing a difference-in-difference Poisson panel regression framework, as well as group-based trajectory analyses, these authors examine the High ...

What makes good guidelines?

In the last two decades, a large number of national and international treatment guidelines have been developed, to assist practioners in making decisions based on available evidence. However, according to a survey of schizophrenia practice guidelines for example [1], the methodological quality of the most guidelines was at best moderate. Hence, national and international institutions attempted ...

Employee attendance: good policy makes good sense

What Makes a Good Footprint?

2. Region approximation [1, 2]. Given a discrete set of points, and for each point whether it lies inside or outside some region of interest, we want to draw a polygon to represent that region. This problem can appear in two guises: (1) the region in question is well-defined, but we either do not know, or do not wish to spare the computational resources to represent, its exact boundary; (2) the...